Run the sx install script under your user (non-root).
$ wget http://sx.dyne.org/install-sx.sh $ bash install-sx.sh usr/
This will install all the required tools in ./usr/
Quick setup guide
Create a blockchain database:
$ mkdir worker/ $ cd worker/ $ mkdir blockchain/ $ sx initchain blockchain/
If you have a bitcoind bootstrap.dat (can also be downloaded off the PirateBay), then you can bootstrap a blockchain. See libbitcoin/tools/ (run 'make' and see the bootstrap tool).
Now start the Bitcoin node which will begin the blockchain download.
$ screen -S worker $ obworker
Press CTRL-C and wait if you want to stop the worker.
You can see the output using 'tail -f debug.log error.log'
Config files are in INSTALL_PREFIX/etc/obelisk/
Important: each worker needs a separate copy of the blockchain database. Multiple workers cannot both use a blockchain database at the same time. Stop the worker, copy the blockchain directory to your other worker and restart obworker.